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People treated with Paxlovid who get rebound COVID should isolate again for 5 days, CDC advises

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People who test positive for COVID-19 again after taking the drug Paxlovid should isolate for another five days, the Centers for Disease Control and Prevention said Tuesday.

There's a chance they might be contagious if they have this rebound effect, said the CDC's Dr. Lauri Hicks.

This is the first time the CDC has issued guidance on what people should do if they test positive again a few days after testing negative for COVID-19. Although the guidance is specific to those taking Paxlovid, Hicks, chief medical officer of CDC's COVID-19 response, said anyone who tests positive or feels poorly again should stay away from others.

"If you get better and then you get worse again or if you decide to test and you have a test that's positive, especially after a negative test result, the recommendation is to re-isolate for at least five more days and continue masking for at least 10 more days," she said.

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